Everything about arthritis rheumatoid symptoms


The majority of people in the world are suffering from an immune system that can't differentiate between healthy cells invading bacteria and disease. The defenses against diseases that were once protecting themselves are now attacking their organs and tissues.




A major international effort in research is underway to stop this trend. A London-based organization, the Francis Crick Institute, has two world-renowned experts. James Lee & Carola Vinuesa set up separate research teams to figure out the root causes of autoimmune disease.


Lee told the Observer that the occurrence of autoimmune diseases began to rise around 40 years ago, in western nations. But, we're now witnessing some cases emerge in countries that had never seen the disease before.


The Middle East, East Asia and Africa have had the highest increase in inflammatory bowel disorder cases over the last few years. Prior to that, they had never seen the disease.


Autoimmune diseases can range from type 1 diabetes to rheumatoid arthritis inflammatory bowel disease and multiple sclerosis. In each of these cases the immune system becomes confused and switches to healthy tissues over infective agents.


The UK is home to at least 4,000,000 individuals suffering from these ailments. There are also many other. In the world, it's thought that cases of autoimmune diseases are growing by between 3% and 9% a year. This rise is thought to be caused by environmental factors, as per the majority of scientists.


Lee who used to be based in Cambridge University, stated that human genetics have not changed in the last few years. There must be a change around the world and it's increasing our susceptibility to an autoimmune disorder.


Vinuesa was in favor of the idea, having previously worked in the Australian National University. She noted that there were changes in the diet because more people were eating western-style meals and increasing consumption of fast food.


Vinuesa said that fast food meals lack some important ingredients such as fiber. Research suggests that this alteration can affect a person's microbiome which is the accumulation of microorganisms living in our digestive tract. These microorganisms play a crucial role in controlling many bodily functions.


These changes in our microbiomes trigger the development of autoimmune diseases, of which more than 100 cases have been reported.


The two scientists emphasized that there were individual susceptibilities to these illnesses. This includes celiac and Lupus. It causes inflammation, swelling, and could cause damage and death to many organs, including heart.


"If you don't have specific genetic susceptibility to autoimmune disease, you won't necessarily get an autoimmune disease regardless of the amount of Big Macs you eat," said Vinuesa. "There isn't much that we can do to stop the global spread of fast-food franchises. So instead we're trying to unravel the genetic causes that cause autoimmune diseases and make some people susceptible but others not. "We would like to tackle the issue at this level."


The advancement of technology has allowed scientists to identify tiny differences in the DNA of large numbers of individuals. In this way, it is possible to find the common genetic patterns that are common to those who suffer from an autoimmune condition.


Lee says that although we had the technology for sequencing DNA to an extent up to a point however, it was not possible. Inflammatory bowel disease was just one of the variants we were able to identify when I began my studies. We now have over 250.


Such work lies at the heart of Lee and Vinuesa's work that aim to find out how these different genetic pathways work and decipher the various types of diseases doctors are investigating. Vinuesa stated that autoimmune disorders such as Lupus for instance are present in many forms, and could have different genetic causes. It can be difficult to identify the appropriate treatment.


We are blessed with a wealth of beneficial new treatments that are developing constantly however, we aren't sure which patients to give them to, because we've realized that we don't know for certain which version of the disease they are suffering from. This is why research into autoimmune diseases has become a priority. We must learn to group and stratify patients, so that we can give them the right treatment.


Lee said that rising cases of autoimmune disease around the world means new treatments and medications are urgently needed more than ever before. There are currently no treatments for autoimmune disorders, which often occur in young people, while they're trying to find their first job, finish the school year, and also raise their families.


That means more Click here people will need to undergo surgery or regular injections throughout their life. This can be extremely stressful for patients, and also stressing the health services. So, it is essential to find effective and new methods of treatment.


Rheumatoid is an auto-immune condition. It is a condition where the immune system is attacking healthy tissues. We don't know what triggers it.


Your immune system naturally creates antibodies to combat bacteria and viruses.


Your immune system could mistakenly send antibodies to your joints if you suffer from rheumatoid. The antibodies attack tissues around them.


The thin layer (synovium), which covers your joints, can be inflamed and inflamed and release chemicals that cause injury.


bones

Cartilage – The connective tissue that is stretchy and connects bones

Tendons - connect muscle to bone

Ligaments form the connective tissue between cartilage and bone.

Rheumatoid arthritis can be treated but not managed. The Read More chemicals can cause joints to become distorted and out of alignment. Eventually, it can destroy the joint completely.


There have been many theories on how the immune system fights joints. One theory is that an infection could be a trigger. However, none of these theories have been proven.


Possible risk factors



Rheumatoid-related arthritis may result from a number of causes, including:


Your genes are a factor - there's evidence to suggest that arthritis may be passed down in families, though the likelihood of passing it on is thought to be low as genes are only thought to play a minor part in the disease

Hormones Rheumatoid arthritis can be more prevalent in women than for males. Though this could be due to the impact of the estrogenic hormones on the body, the cause has not been established.

Smoking cigarettes - There is evidence that smoking increases the risk of developing rheumatoid arthritis.

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